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NHS Foundation Trust  
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 Formulary Chapter 2: Cardiovascular system - Full Chapter
02.01  Positive inotropic drugs
02.01.01  Cardiac glycosides
Digoxin
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Formulary
Green

Tablets, elixir, injection

Note: Bioavailability
Tablets 125 micrograms = elixir 100 micrograms =injection 85 micrograms

 
   
02.01.01  Digoxin-specific antibody
Digoxin specific antibody fragments (Digifab)
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Formulary
Red
Injection 
   
02.01.02  Phosphodiesterase type-3 inhibitors
Milrinone (Primacor)
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Formulary
Red
Injection 
   
02.02  Diuretics to top
02.02.01  Thiazides and related diuretics
Bendroflumethiazide
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Formulary
Green

Tablets

 
   
Indapamide
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Formulary
Green

Tablets, m/r tablets

 
   
02.02.02  Loop diuretics
Bumetanide
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Formulary
Green

Tablets, oral liquid

Injection discontinued 2012

 
   
Furosemide
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Formulary
Green

Tablets, oral solution, injection

 
   
02.02.03  Potassium-sparing diuretics and aldosterone antagonists
Amiloride Hydrochloride
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Formulary
Green

Tablets, oral solution

 
   
02.02.03  Aldosterone antagonists
Eplerenone
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Formulary
Amber
Tablets 
   
Spironolactone
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Formulary
Green

Tablets, oral suspension (unlicensed)

 
   
02.02.04  Potassium-sparing diuretics with other diuretics to top
Co-amilofruse (furosemide and amiloride)
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Formulary
Green

Tablets

 
   
Co-amilozide
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Formulary
Green

Tablets

 
   
Co-triamterzide
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Formulary
Green

Tablets

 
   
02.02.05  Osmotic diuretics
Mannitol
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Formulary
Red

i/v infusion

 
   
02.02.06  Mercurial diuretics
02.02.07  Carbonic anhydrase inhibitors
02.02.08  Diuretics with potassium
02.03  Anti-arrhythmic drugs to top
02.03.01  Management of arrhythmias
02.03.02  Drugs for arrhythmias
02.03.02  Supraventricular arrhythmias
Adenosine (Adenocor)
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Formulary
Red

Injection, i/v infusion

 
   
Dronedarone (Multaq)
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Restricted Drug Restricted
Red

Tablets

 
Link  MHRA Oct 2011: Cardiovascular, hepatic and pulmonary adverse effects - restrictions and monitoring requirements
   
02.03.02  Supraventricular and ventricular arrhythmias
Amiodarone
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Formulary
Amber
Tablets (Amber)

Injection (Red) 
   
Disopyramide
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Formulary
Amber

Capsules, injection

 
   
Flecainide
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Formulary
Green

Tablets, injection

 
   
Propafenone
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Formulary
Green

Tablets

 
   
02.03.02  Ventricular arrhythmias to top
Lidocaine
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Formulary
Amber

i/v infusion

 
   
02.04  Beta-adrenoceptor blocking drugs
Atenolol
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Formulary
Green

Tablets, syrup, injection

 
   
Bisoprolol
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Formulary
Green

Tablets

 
   
Carvedilol
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Formulary
Green

Tablets

 
   
Co-tenidone (atenolol and chlortalidone)
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Formulary
Green

Tablets

 
   
Esmolol
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Formulary
Amber

Injection

 
   
Labetalol
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Formulary
Green

Tablets

 
   
Metoprolol
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Formulary
Green

Tablets, injection

 
   
Nebivolol
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Formulary
Green

Tablets

 
   
Oxprenolol Hydrochloride
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Formulary
Green

Tablets

 
   
Propranolol
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Formulary
Green

Tablets, m/r capsules, oral solution

 
   
Sotalol
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Formulary
Green

Tablets

 
   
02.05  Drugs affecting the renin-angiotensin system and some other antihypertensive drugs
02.05.01  Vasodilator antihypertensive drugs
Diazoxide (Eudemine)
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Formulary
Amber

tablets and oral suspension (Unlicensed)

 
   
Hydralazine
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Formulary
Green

Tablets, injection

 
   
Minoxidil
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Formulary
Green

Tablets

 
   
Sodium Nitroprusside
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Formulary
Amber

Injection

 
   
02.05.02  Centrally acting antihypertensive drugs
Clonidine Hydrochloride
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Formulary
Green

Tablets

 
   
Methyldopa
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Formulary
Green

Tablets

 
   
Moxonidine
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Formulary
Green

Tablets

 
   
02.05.03  Adrenergic neurone blocking drugs to top
Guanethidine Monosulphate (Ismelin)
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Formulary
Amber

Injection

 
   
02.05.04  Alpha-adrenoceptor blocking drugs
Doxazosin
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Formulary
Green

Tablets, m/r tablets

 
   
Prazosin
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Formulary
Green

Tablets

 
   
Terazosin
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Formulary
Green

Tablets

 
   
02.05.04  Phaeochromocytoma
Phentolamine Messilate (Rogitine)
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Formulary
Amber

Injection (unlicensed)

 
   
02.05.05  Drugs affecting the renin-angiotensin system
02.05.05  Heart Failure
02.05.05.01  Angiotensin-converting enzyme inhibitors (ACE inhibitors) to top
Ramipril
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First Choice
Green

Capsules

 
Lisinopril
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Second Choice
Green

Tablets

 
   
Captopril
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Formulary
Green

Tablets

 
   
Enalapril
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Formulary
Green

Tablets

 
   
Fosinopril Sodium
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Formulary
Green

Tablets

 
   
Perindopril
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Formulary
Green

Tablets

 
   
Quinapril
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Formulary
Green

Tablets

 
   
Trandolapril
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Formulary
Green

Capsules

 
   
02.05.05.02  Angiotensin-II receptor antagonists
Candesartan
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First Choice
Green

Tablets

 
Irbesartan
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Formulary
Green

Tablets

 
   
Losartan
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Formulary
Green

Tablets

 
   
Olmesartan
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Formulary
Green

Tablets

 
   
Valsartan
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Formulary
Green

Capsules

 
   
02.05.05.03  Renin inhibitors
Aliskiren (Rasilez)
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Formulary
Amber
Tablets 
   
02.06  Nitrates, calcium-channel blockers, and potassium-channel activators
02.06  Angina
02.06.01  Nitrates to top
Glyceryl Trinitrate
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Formulary
Green

Spray 400 micrograms
Sublingual tablets 300 microgram and 500 micrograms
Patches 5 mg, 10 mg
i/v infusion

 
   
Isosorbide Mononitrate
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Formulary
Green

Tablets, m/r tablets (60mg)

 
   
Isosorbide Dinitrate
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Formulary
Green

Tablets

 
   
02.06.02  Calcium-channel blockers
Amlodipine
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Formulary
Green

Tablets

 
   
Diltiazem
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Formulary
Green

m/r capsules once daily (Slozem 120 mg, 180 mg, 240 mg, 300 mg)
m/r tablets twice daily (Tildiem Retard 90 mg, 120 mg)


 
   
Felodipine
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Formulary
Green

m/r tablets

 
   
Lacidipine
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Formulary
Green

Tablets

 
   
Lercanidipine Hydrochloride
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Formulary
Green

Tablets

 
   
Nicardipine Hydrochloride
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Formulary
Green

Capsules

 
   
Nifedipine
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Formulary
Green

Capsules (immediate release 5, mg, 10 mg)
Capsules m/r twice daily (Coracten SR 10 mg, 20 mg)
Capsules m/r once daily (Coracten XL 30 mg, 60 mg)

 
   
Nimodipine
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Formulary
Red

Tablets

 
   
Verapamil Hydrochloride
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Formulary
Green

Tablets, m/r tablets, oral solution, injection

 
   
02.06.03  Other anitanginal drugs
Ivabradine
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Formulary
Amber
Tablets 
   
Nicorandil
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Formulary
Green

Tablets

 
   
Ranolazine
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Formulary
Amber
m/r tablets 
   
02.06.04  Peripheral vasodilators and related drugs
Naftidrofuryl Oxalate
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Formulary
Green

Capsules

 
   
Pentoxifylline (Trental)
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Formulary
Green

m/r tablets

 
   
02.06.04  Other preparations used in peripheral vascular disease
Oxerutins (Paroven)
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Formulary
Amber

Capsules

 
   
02.07  Sympathomimetics to top
02.07.01  Inotropic sympathomimetics
Dobutamine
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Formulary
Amber

Injection

 
   
Dopamine
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Formulary
Amber

Injection

 
   
02.07.02  Vasoconstrictor sympathomimetics
Ephedrine
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Formulary
Amber

Injection

 
   
Metaraminol
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Formulary
Amber

Injection

 
   
Noradrenaline / Norepinephrine
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Formulary
Amber

Injection 1 in 1000

 
   
Phenylephrine
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Formulary
Amber

Injection

 
   
02.07.03  Cardiopulmonary resuscitation
Adrenaline / Epinephrine
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Formulary
Amber

Injection

 
   
02.08  Anticoagulants and protamine
02.08.01  Parenteral anticoagulants to top
02.08.01  Heparin
Heparin
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Formulary
Amber

Injection 1000 units/mL

 
   
02.08.01  Low molecular weight heparins
Tinzaparin (Innohep)
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Formulary
Amber
Prefilled syringes 
Link  Tinzaparin Prescribing Advice: VTE Prophylaxis and Treatment in Adults
   
02.08.01  Heparinoids
02.08.01  Hirudins
02.08.01  Heparin flushes to top
Heparin
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Formulary
Amber

Heparinised saline flushes

 
   
02.08.01  Epoprostenol
Epoprostenol (Flolan)
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Formulary
Amber

Infusion

 
   
02.08.01  Fondaparinux
Fondaparinux Sodium (Arixtra)
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Formulary
Amber

Prefilled syringes

Acute coronary syndromes

 
   
02.08.02  Oral anticoagulants
Acenocoumarol (Sinthrome)
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Formulary
Amber

Tablets

 
   
Apixaban (Eliquis )
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Formulary
Green

Tablets

 
   
Dabigatran etexilate (Pradaxa)
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Restricted Drug Restricted
Green

Capsules

VTE prophylaxis - elective hip and knee surgery

 
Link  MHRA clarification on contraindications, 2012
   
Phenindione
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Formulary
Amber

Tablets

 
   
Rivaroxaban (Xarelto)
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Restricted Drug Restricted
Green

Tablets
Atrial fibrilation - local guidelines
DVT - local guidelines

 
   
Warfarin
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Formulary
Green

Tablets 1 mg only

 
   
02.08.03  Protamine sulphate
Protamine Sulphate
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Formulary
Amber

Injection

 
   
02.09  Antiplatelet drugs to top
Aspirin (antiplatelet)
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Formulary
Green

Enteric coated tablets, soluble tablets, suppositories

 
   
Clopidogrel
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Formulary
Green

Tablets

 
   
Dipyridamole
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Formulary
Green

Tablets, m/r capsules

 
   
Dipyridamole and Aspirin (Asasantin Retard)
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Formulary
Green

Capsules

 
   
Prasugrel (Efient)
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Formulary
Amber
Tablets 
Link  MHRA safety information on hypersensitivity May 2011
   
Ticagrelor (Brilique)
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Formulary
Amber
Tablets 
   
Tirofiban (Aggrastat)
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Formulary
Amber

Concentrate for i/v infusion

 
   
02.10  Stable angina, acute coronary syndromes, and fibrinolysis
02.10.01  Management of stable angina and acute coronary syndromes
02.10.02  Fibrinolytic drugs
Alteplase (Actilyse)
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Formulary
Red

Injection

 
   
Streptokinase
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Formulary
Red

Injection

 
   
Urokinase
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Formulary
Red

Injection

Indication: occluded venous catheters

 
   
02.11  Antifibrinolytic drugs and haemostatics
Tranexamic Acid
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Formulary
Green

Tablets, syrup, injection

 
Link  DTB review:OTC tranexamic acid for heavy menstrual bleeding (password protected)
   
02.11  Blood-related products to top
02.12  Lipid-regulating drugs
02.12  Statins
Simvastatin
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First Choice
Green

Tablets

 
Atorvastatin
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Second Choice
Green

Tablets

 
Link  MHRA advice on atorvastatin interactions and doses (NB information on simvastatin contained in this has been superseded- see simvastatin)
   
Pravastatin
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Formulary
Green

Tablets

 
   
Rosuvastatin
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Formulary
Green

Tablets

 
   
02.12  Bile acid sequestrants
Colesevelam (Cholestagel)
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Formulary
Green

Tablets

 
   
Colestyramine
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Formulary
Green

Sachets Questran Light

 
   
02.12  Ezetimibe
Ezetimibe (Ezetrol)
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Formulary
Green

Tablets

 
   
02.12  Fibrates to top
Bezafibrate
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Formulary
Green

Tablets, m/r tablets

 
   
Fenofibrate
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Formulary
Green

Capsules (Micronised)

 
   
02.12  Nicotinic acid group
02.12  Omega-3 fatty acid compounds
Omega-3-Acid Ethyl Esters (Omacor)
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Formulary
Green

Capsules

 
   
02.13  Local sclerosants
 ....
 Non Formulary Items
Etamsylate  (Dicynene)

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Non Formulary
Red

Tablets (unlicensed)

 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

Traffic Light Status Information

Status Description

Amber

used  

Green

Green  

Red

Red  

netFormulary