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 Formulary Chapter 4: Central nervous system - Full Chapter
04.01  Hypnotics and anxiolytics
04.01.01  Hypnotics
Melatonin  (Circadin ®)
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Formulary m/r tablets 
   
04.01.01  Benzodiazepines
Nitrazepam
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Formulary Tablets, oral suspension 
   
Controlled Drug Temazepam
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Formulary Tablets, oral solution 
   
04.01.01  Zaleplon, Zolpidem and Zopiclone
Zaleplon (Sonata®)
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Restricted Drug Restricted Capsules 
   
Zolpidem
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Restricted Drug Restricted Tablets 
   
Zopiclone
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Formulary Tablets 
   
04.01.01  Chloral and derivatives to top
Chloral Hydrate
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Formulary Syrup 500 mg/5mL (unlicensed preparation) 
   
Cloral Betaine (Welldorm®)
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Restricted Drug Restricted Tablets 
   
04.01.01  Clomethiazole (Chlormethiazole)
Clomethiazole (Heminevrin®)
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Formulary Capsules  
   
04.01.01  Antihistamines
Promethazine Hydrochloride
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Formulary Tablets, elixir, injection 
   
04.01.01  Alcohol
04.01.01  Sodium oxybate
04.01.02  Anxiolytics to top
04.01.02  Benzodiazepines
Chlordiazepoxide Hydrochloride
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Formulary Capsules 
   
Diazepam
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Formulary Tablets, suspension, rectal tubes, injection (aqueous, emulsion) 
   
Lorazepam
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Formulary Tablets 
   
Oxazepam
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Formulary Tablets 
   
04.01.02  Buspirone
Buspirone Hydrochloride
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Formulary Tablets 
   
04.01.02  Beta blockers
04.01.02  Meprobamate
04.01.03  Barbiturates to top
Controlled Drug Amobarbital (amylobrbitone) (Sodium Amytal®)
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Formulary Tablets 
   
04.02  Drugs used in psychoses and related disorders
04.02.01  Antipsychotic Drugs
Benperidol (Anquil®)
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Formulary
Amber
Tablets 
   
Chlorpromazine
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Formulary Tablets, syrup, injection 
   
Flupentixol (Depixol®)
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Formulary Tablets 
   
Haloperidol
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Formulary Capsules 500 micrograms

Tablets, oral liquid, injection 
   
Levomepromazine (Nozinan®)
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Formulary Tablets, injection 
   
Pericyazine (Neilactil®)
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Formulary Tablets 
   
Perphenazine (Fentazin®)
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Formulary Tablets 
   
Prochlorperazine
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Formulary Tablets, syrup, injection 
   
Promazine Hydrochloride (Promazine®)
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Formulary Oral solution 
   
Sulpiride
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Formulary Tablets 
   
Trifluoperazine
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Formulary Tablets, syrup 
   
Zuclopenthixol (Clopixol®)
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Formulary Tablets 
   
Zuclopenthixol Acetate (Clopixol Acuphase®)
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Formulary Injection 
   
04.02.01  Second-Generation Antipsychotic Drugs
Amisulpride
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Formulary
Amber
Tablets 
   
Aripiprazole (Abilify®)
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Formulary
Amber
Tablets, dispersible tablets, oral solution
(Amber)

Injection (Red) 
   
Clozapine (Zaponex®)
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Formulary
Red
Tablets 
   
Olanzapine
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Formulary
Amber
Tablets, orodispersible tablets 
   
Quetiapine
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Formulary
Amber
Tablets, m/r tablets 
   
Risperidone
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Formulary Tablets, orodispersible tablets, oral liquid 
   
04.02.02  Antipsychotic depot injections
Flupentixol Decanoate (Depixol®)
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Formulary Depot injection 
   
Flupentixol Decanoate (Depixol® Conc.)
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Formulary Depot injection 
   
Flupentixol Decanoate (Depixol® Low Volume)
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Formulary Depot injection 
   
Fluphenazine Decanoate
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Formulary Depot injection 
   
Fluphenazine Decanoate (Modecate®)
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Formulary Depot injection 
   
Fluphenazine Decanoate (Modecate® Concentrate)
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Formulary Depot injection 
   
Haloperidol (Haldol Decanoate®)
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Formulary Depot injection 
   
Pipotiazine Palmitate (Piportil® Depot)
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Formulary Depot injection 
   
Risperidone (Risperdal Consta®)
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Formulary
Green
Depot injection 
   
Zuclopenthixol Decanoate (Clopixol®)
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Formulary Depot injection 
   
Zuclopenthixol Decanoate (Clopixol® Conc.)
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Formulary Depot injection 
   
04.02.03  Antimanic drugs to top
Lamotrigine
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Formulary Tablets 
   
Pregabalin
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Formulary Capsules 
   
04.02.03  Benzodiazepines
Clonazepam
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Formulary Tablets 
   
04.02.03  Antipsychotic drugs
04.02.03  Carbamazepine
Carbamazepine
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Formulary Tablets, m/r tablets 
   
04.02.03  Valproic acid
Valproic Acid (Depakote®)
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Formulary Tablets 
   
04.02.03  Lithium to top
Lithium Carbonate (Camcolit®)
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Formulary Tablets, m/r tablets 
   
Lithium Carbonate (Liskonum®)
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Formulary m/r tablets 
   
Lithium Carbonate (Priadel®)
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Formulary m/r tablets 
   
Lithium Citrate (Li-Liquid®)
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Formulary Oral solution 
   
04.03  Antidepressant drugs
04.03.01  Tricyclic and related antidepressant drugs
04.03.01  Tricyclic antidepressants
Amitriptyline Hydrochloride
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Formulary Tablets, oral solution 
   
Clomipramine Hydrochloride
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Formulary Capsules 
   
Dosulepin Hydrochloride
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Formulary Capsules 25 mg, tablets 75 mg 
   
Doxepin (Sinepin®)
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Formulary Capsules 
   
Imipramine Hydrochloride
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Formulary Tablets 
   
Lofepramine
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Formulary Tablets, oral suspension 
   
Nortriptyline (Allegron®)
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Formulary  
   
Trimipramine (Surmontil®)
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Formulary Tablets 25 mg, capsules 50 mg
 
   
04.03.01  Related antidepressants
Mianserin Hydrochloride (Mianserin®)
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Formulary
Amber
 
   
Trazodone Hydrochloride
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Formulary Capsules 
   
04.03.02  Monoamine-oxidase inhibitors to top
Phenelzine (Nardil®)
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Formulary
Red
Tablets 
   
Safinamide (®)
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Formulary Tablets 
   
04.03.02  Reverible MAOIs
Moclobemide
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Formulary  
   
04.03.03  Selective serotonin re-uptake inhibitors
Citalopram
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Formulary Tablets, oral drops 
   
Escitalopram (Cipralex®)
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Formulary
Amber
Tablets 
   
Fluoxetine
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Formulary Capsules, oral liquid 
   
Fluvoxamine Maleate (Fluvoxamine®)
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Formulary Tablets 
   
Paroxetine
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Formulary Tablets, oral liquid 
   
Sertraline
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Formulary Tablets 
   
04.03.04  Other antidepressant drugs
Agomelatine (Valdoxan®)
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Formulary
Red
Tablets 
   
Duloxetine (Cymbalta®)
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Formulary Capsules 
   
Duloxetine (Ventreve®)
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Formulary  
   
Flupentixol (Fluanxol®)
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Formulary Tablets 
   
Mirtazapine
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Formulary Orodispersible tablets 
   
Reboxetine (Edronex®)
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Formulary
Amber
Tablets 
   
Tryptophan
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Formulary
Red
Tablets 
   
Venlafaxine
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Formulary Tablets, m/r capsules 
   
04.04  CNS stimulants and other drugs used for attention deficit hyperactivity disorder
Atomoxetine (Strattera®)
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Formulary
Amber
Tablets 
   
Controlled Drug Dexamfetamine Sulphate (Dexedrine®)
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Formulary Tablets 
   
Controlled Drug Methylphenidate Hydrochloride
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Formulary Tablets, m/r tablets

m/r capsules (Equasym XL) restricted use 
   
Modafinil (Provigil®)
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Formulary
Amber
Tablets 
   
04.04  Cocaine to top
04.05  Drugs used in the treatment of obesity
04.05.01  Anti-obesity drugs acting on the gastro-intestingal tract
04.05.02  Centrally acting appetite suppressants
04.06  Drugs used in nausea and vertigo
04.06  Vomiting during pregnancy to top
04.06  Postoperative nausea and vomiting
04.06  Motion sickness
04.06  Other vestibular disorders
04.06  Cytotoxic chemotherapy
04.06  Palliative care to top
04.06  Migraine
04.06  Antihistamines
Cinnarizine
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Formulary Tablets 
   
Cyclizine (Valoid®)
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Formulary Tablets, injection 
   
Promethazine Hydrochloride
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Formulary  
   
04.06  Phenothiazines and related drugs
Chlorpromazine Hydrochloride
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Formulary  
   
Droperidol (Xomolix®)
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Formulary Injection 
   
Levomepromazine (methotrimeprazine)
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Formulary Tablets, injection 
   
Perphenazine
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Formulary  
   
Prochlorperazine
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Formulary Tablets, syrup, buccal tablets, injection 
   
Trifluoperazine
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Formulary Tablets 
   
04.06  Domperidone and metoclopramide
Domperidone
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Formulary Tablets, suspension, suppositories 
   
Metoclopramide Hydrochloride
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Formulary Tablets, syrup, injection 
   
04.06  5HT3 antagonists to top
Granisetron
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Formulary Tablets, injection

Transdermal patch  
   
Ondansetron
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Formulary
Amber
Tablets, orodispersible tablets, orodispersible film, syrup, injection 
   
04.06  Neurokinin receptor antagonist
Aprepitant (Emend®)
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Formulary Capsules 80mg, 125mg

Capsules 3 day pack 
   
04.06  Cannabinoid
04.06  Hyoscine
Hyoscine Hydrobromide
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Formulary Tablets, patches 
   
04.06  Other drugs for Ménière's disease
Betahistine Dihydrochloride
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Formulary Tablets 
   
04.07  Analgesics to top
04.07.01  Non-opioid analgesics and compound analgesic preparations
04.07.01  Compound analgesic preparations
Aspirin
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Formulary Tablets, e/c tablets, soluble tablets 
   
Nefopam
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Formulary Tablets 
Link  Cochrane review:nefopam for acute post- op pain
   
Paracetamol
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Formulary Tablets, soluble tablets, suspension, suppositories,

i/v infusions 
   
Paracetamol and codeine (Co-codamol® 30/500)
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Formulary Tablets, soluble tablets 
   
Paracetamol and codeine (Co-codamol® 8/500)
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Formulary Tablets, soluble tablets 
   
Paracetamol and dihydrocodeine (Co-dydramol®)
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Formulary Tablets 
   
04.07.02  Opioid analgesics
Controlled Drug Buprenorphine (Temgesic®)
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Formulary Sublingual tablets 
   
Controlled Drug Buprenorphine (BuTrans® patch)
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Formulary 7 day patch 
   
Controlled Drug Buprenorphine (Transtec® patch)
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Formulary 96 hour patch 
   
Codeine Phosphate
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Formulary Tablets, injection 
Controlled Drug Injection Only
   
Controlled Drug Diamorphine
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Formulary Injections 
   
Dihydrocodeine
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Formulary Tablets, m/r tablets, oral solution, injection 
Controlled Drug Injection Only
   
Controlled Drug Fentanyl
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Formulary Buccal tablets (Effentora)
Sublingual tablets (Abstral)
Lozenges (Actiq)

Patches:
First line - Matrifen for new patients
Second line - Durogesic DTrans for patients already prescribed this brand 
   
Controlled Drug Fentanyl
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Formulary  
   
Controlled Drug Methadone
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Formulary  
   
Controlled Drug Morphine
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Formulary Oral solution, injections

m/r capsules (Zomorph)

m/r tablets 5 mg (MST) 
   
Controlled Drug Morphine Salts (Sevredol®)
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Formulary  
   
Controlled Drug Oxycodone
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Formulary Normal release - capsules, liquid, injection

m/r tablets 
   
Controlled Drug Pethidine
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Formulary Injection 
   
Controlled Drug Targinact (Oxycodone/Naloxone) (Targinact®)
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Restricted Drug Restricted Tablets 
   
Tramadol
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Formulary Capsules, soluble tablets 
   
04.07.03  Neuropathic pain
Gabapentin
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Formulary Capsules 
   
Ketamine oral solution
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Formulary  
   
Pregabalin
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Formulary Capsules 
   
04.07.03  Trigeminal neuralgia to top
Carbamazepine
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Formulary Tablets, m/r tablets 
   
Phenytoin
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Formulary Capsules, oral suspension

Bioavailability: 100 mg capsules = 90 mg oral suspension 
   
04.07.03  Postherpetic neuralgia
Amitriptyline
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Formulary Tablets, oral solution 
   
Carbamazepine
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Formulary Tablets, suspension, m/r tablets, suppositories 
   
04.07.03  Chronic facial pain
04.07.04  Antimigraine drugs
04.07.04.01  Treatment of the acute migraine attack
04.07.04.01  Analgesics to top
04.07.04.01  5HT1 agonists
Sumatriptan
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First Choice Tablets, nasal spray, injection 
Zolmitriptan (Zomig®)
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Formulary Tablets 
   
04.07.04.01  Ergot alkaloids
04.07.04.01  Anti-emetics
04.07.04.01  Other drugs for migrane
04.07.04.02  Prophylaxis of migraine to top
Amitriptyline
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Formulary Tablets, oral solution 
   
Clonidine Hydrochloride
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Formulary Tablets 
   
Pizotifen
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Formulary Tablets, elixir 
   
Propranolol
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Formulary Tablets, m/r capsules, oral solution 
   
Sodium valproate
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Formulary e/c tablets, m/r tablets, crushable tablets, liquid, injection 
   
Topiramate
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Formulary Tablets, Sprinkle capsules 
   
04.07.04.03  Cluster headache
Melatonin
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Formulary  
   
04.08  Antiepileptics
04.08.01  Control of epilepsy
04.08.01  Partial seizures with or without secondary generalisation
04.08.01  Generalised seizures to top
04.08.01  Carbamazepine and Oxcarbazepine
Carbamazepine
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Formulary Tablets, chewable tablets, m/r tablets, suspension,suppositories 
   
Oxcarbazepine (Trileptal®)
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Formulary
Amber
Tablets, oral suspension 
   
04.08.01  Ethosuximide
Ethosuximide
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Formulary Capsules, syrup 
   
Ethosuximide (Emeside®)
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Formulary  
   
04.08.01  Gabapentin and pregabalin
Gabapentin
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First Choice Capsules 
Pregabalin
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Formulary Capsules 
   
04.08.01  Lacosamide
04.08.01  Lamotrigine to top
Lamotrigine
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Formulary Tablets, soluble tablets 
   
04.08.01  Levetiracetam
Levetiracetam
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Formulary Tablets, oral solution, concentrate for infusion 
   
04.08.01  Phenobarbital and other barbiturates
Controlled Drug Phenobarbital
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Formulary Tablets, elixir, injection 
   
Primidone (Mysoline®)
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Formulary  
   
04.08.01  Phenytoin
Phenytoin
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Formulary Capsules, oral suspension, injection

Bioavailability: 100 mg capsules = 90 mg oral suspension 
   
04.08.01  Retigaine
04.08.01  Rufinamide to top
04.08.01  Tiagabine
Tiagabine (Gabitril®)
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Formulary
Amber
 
   
04.08.01  Topiramate
Topiramate
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Formulary
Amber
Tablets, Sprinkle capsules 
   
04.08.01  Valproate
Sodium Valproate
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Formulary e/c tablets, m/r tablets, crushable tablets, liquid, injection 
   
04.08.01  Vigabatrin
Vigabatrin (Sabril®)
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Formulary
Amber
Tablets, sachets 
   
04.08.01  Zonisamide to top
04.08.01  Benzodiazepines
Clobazam
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Formulary
Amber
Tablets 
   
Clonazepam
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Formulary Tablets 
   
04.08.01  Other Drugs
Acetazolamide
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Formulary
Amber
 
   
04.08.02  Drugs used in status epilepticus
Clonazepam
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Formulary Injection 
   
Diazepam
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Injections (solution, emulsion), rectal tubes 
   
Lorazepam
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Injection 
   
Controlled Drug Midazolam (Buccolam®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Oromucosal solution 
   
Paraldehyde
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Formulary Paraldehyde and olive oil 50/50 enema 
   
Controlled Drug Phenobarbital
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Injection 
   
Phenytoin
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Injection 
   
04.08.03  Febrile convulsions
Diazepam
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Formulary  
   
Paracetamol
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Formulary  
   
04.09  Drugs used in parkinsonism and related disorders to top
04.09.01  Dopaminergic drugs used in Parkinsons disease
04.09.01  Dopamine receptor agonists
Apomorphine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber
Prefilled pen 
   
Bromocriptine
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Formulary Tablets 1 mg, 2.5 mg; Capsules 10 mg 
   
Cabergoline (Cabaser®)
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Formulary Tablets 
   
Pergolide
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Formulary
Amber
Tablets 
   
Pramipexole
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber
Tablets, m/r tablets 
   
Ropinirole
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Formulary
Amber
Tablets, m/r tablets 
   
Rotigotine
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Formulary
Amber
Patches 
   
04.09.01  Levodopa
Co-Beneldopa (Madopar®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Capsules, dispersible tablets 
   
Co-Beneldopa (Madopar®CR)
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Formulary m/r tablets 
   
Co-Careldopa (Half Sinemet ®CR)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary m/r tablets 
   
Co-Careldopa (Sinemet®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Tablets 
   
Co-Careldopa (Sinemet® CR)
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Formulary m/r tablets 
   
Co-Careldopa and Entacapone (Stalevo®)
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Formulary
Amber
Tablets 
   
04.09.01  Monoamine-oxidase-B inhibitors
Rasagiline (Azilect®)
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Formulary
Amber
Tablets 
   
Selegiline Hydrochloride
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Formulary Tablets 
   
04.09.01  Catachol-O-methyltransferase inhibitors to top
Entacapone (Comtess®)
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Formulary
Amber
Tablets 
   
04.09.01  Amantadine
Amantadine Hydrochloride (Symmetrel®)
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Formulary Tablets 
   
04.09.02  Antimuscarinic drugs used in parkinsonism
Orphenadrine Hydrochloride
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Formulary Tablets 
   
Procyclidine Hydrochloride
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Formulary Tablets, syrup, injection 
   
Trihexyphenidyl Hydrochloride
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Tablets, syrup 
   
04.09.03  Drugs used in essential tremor, chorea, tics, and related disorders
Haloperidol
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Tablets, oral solution, injection 
   
Primidone
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Formulary
Amber
 
   
Propranolol
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Formulary  
   
04.09.03  Torsion dystonias and other involuntary movements
Botulinum Toxin Type A (Botox®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Injection 
Link  NICE TA260: Botox for migraine prophylaxis
   
Botulinum Toxin Type A (Dysport®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Injection 
   
Botulinum Toxin Type A (Xeomin®)
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Formulary Injection 
   
04.10  Drugs used in substance dependence to top
04.10  Alcohol dependence
04.10  Cigarette smoking
04.10  Opioid dependence
04.10.01  Alcohol dependence
Acamprosate Calcium (Campral EC®)
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Formulary
Amber
Tablets  
   
Disulfiram (Antabuse®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber
Tablets 
   
Naltrexone
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
Tablets 
   
04.10.02  Nicotine dependence to top
Nicotine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Nicorette: Invisipatches (16 hours), Inhalator (15 mg),
Mini Lozenges, oral spray (Quickmist)

 
   
04.10.03  Opioid dependence
04.10.03  Opioid substitution therapy
Controlled Drug Buprenorphine (Subutex®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
Sublingual tablets 
   
Controlled Drug Methadone
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Tablets, oral solution, injection  
   
04.10.03  Adjunctive therapy and symptomatic treatment
Lofexidine Hydrochloride (BritLofex®)
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary Tablets 
   
04.10.03  Opioid-receptor antagonists
Naltrexone Hydrochloride (Nalorex®)
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Formulary Tablets 
   
04.11  Drugs for dementia to top
Donepezil
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber
Tablets, orodispersible tablets 
   
Galantamine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Amber
Tablets, oral solution, m/r capsules 
   
Memantine
View adult BNF View SPC online View childrens BNF  Track Changes
Formulary
Red
Tablets, metered dose oral solution 
   
Rivastigmine
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Formulary
Amber
Capsules, oral solution, patches (24 hour) 
   
 ....
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

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Amber

used  

Green

Green  

Red

Red  

netFormulary