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 Formulary Chapter 8: Malignant disease and immunosuppression - Full Chapter
08.01  Cytotoxic drugs
Cytotoxic Drug Bosutinib (Bosulif)
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Restricted Drug Restricted
Red

Tablet

 
Link  NICE TA401 Bosutinib for previously treated chronic myeloid leukaemia (2016)
   
Cytotoxic Drug Idelalisib (Zydelig®)
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Restricted Drug Restricted
Red
Tablets 
   
08.01  Side-effects of cytotoxic drugs
08.01  Drugs for cytotoxic-induced side-effects
Calcium Folinate
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Formulary
Red
Tablets, injection 
   
Mesna
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Formulary
Red
Tablets, injection 
   
08.01.01  Alkylating drugs
Bendamustine
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Formulary
Red
Injection 
Link  NICE TA216: Bendamustine for CLL
   
Cytotoxic Drug Busulfan
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Formulary
Red
Tablets 
   
Cytotoxic Drug Carmustine (BiCNU®)
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Formulary
Red
Injection 
   
Cytotoxic Drug Chlorambucil
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Formulary
Red
Tablets 
   
Cytotoxic Drug Cyclophosphamide
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Formulary
Red
Tablets, injection 
   
Cytotoxic Drug Ifosfamide (Mitoxana®)
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Formulary
Red
Injection 
   
Cytotoxic Drug Melphalan
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Formulary
Red
Tablets 
   
08.01.02  Anthracyclines and other cytotoxic antibiotics to top
Cytotoxic Drug Bleomycin
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Formulary
Red
Injection 
   
Cytotoxic Drug Daunorubicin
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Formulary
Red
Injection 
   
Cytotoxic Drug Doxorubicin Hydrochloride
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Formulary
Red
Injection 
   
Cytotoxic Drug Epirubicin hydrochloride
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Formulary
Red
Injection 
   
Cytotoxic Drug Idarubicin Hydrochloride (Zavedos®)
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Formulary
Red

Injection

 
   
Cytotoxic Drug Mitomycin
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Formulary
Red
Injection 
   
Cytotoxic Drug Mitoxantrone (Mitozantrone)
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Formulary
Red
Injection 
   
Cytotoxic Drug Pixantrone (Pixuvri®)
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Restricted Drug Restricted
Red
High Cost Medicine
Injection for infusion 
Link  NICE TA 306: Pixantrone monotherapy for treating multiply relapsed or refractory aggressive non-Hodgkin’s B‑cell lymphoma
   
08.01.03  Antimetabolites
Cytotoxic Drug Azacitidine (Vidaza®)
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Formulary
Red
Injection 
Link  NICE TA218: azacitidine for myelodysplastic syndromes
   
Cytotoxic Drug Capecitabine (Xeloda®)
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Formulary
Red
Tablets 
   
Cytotoxic Drug Cladribine
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Formulary
Red
Injection 
   
Cytotoxic Drug Clofarabine (Evoltra®)
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Formulary
Red
Injection 
   
Cytotoxic Drug Cytarabine
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Formulary
Red
Injection 
   
Cytotoxic Drug Fludarabine Phosphate (Fludara®)
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Formulary
Red
Injection 
   
Cytotoxic Drug Fluorouracil
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Formulary
Red
Injection 
   
Cytotoxic Drug Gemcitabine (Gemzar®)
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Formulary
Red
Injection 
   
Cytotoxic Drug Mercaptopurine
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Formulary Tablets 
   
Cytotoxic Drug Methotrexate
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Formulary Tablets, injection 
   
08.01.04  Vinca alkaloids and etoposide
Cytotoxic Drug Etoposide
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Formulary
Red
Capsules, injection 
   
Cytotoxic Drug Vinblastine Sulphate
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Formulary
Red
Injection 
   
Cytotoxic Drug Vincristine Sulphate
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Formulary
Red
Injection 
   
Vindesine Sulphate (Eldisine®)
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Formulary
Red
 
   
Cytotoxic Drug Vinorelbine
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Formulary
Red
Capsules 
   
08.01.05  Other antineoplastic drugs
Cytotoxic Drug Carfilzomib (Kyprolis)
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Restricted Drug Restricted
Red

Solution for infusion

 
Link  NICE TA457 Carfilzomib for previously treated multiple myeloma (2017)
   
Cytotoxic Drug Crizotinib (Xalkori)
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Restricted Drug Restricted
Red

Capsule

 
Link  NICE TA406 Crizotinib for untreated anaplastic lymphoma kinase-positive advanced non-small-cell lung cancer (2016)
   
Cytotoxic Drug Ibrutinib  (Imbruvica)
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Restricted Drug Restricted
Red

Capsule

 
Link  NICE TA491 Ibrutinib for treating Waldenstrom’s macroglobulinaemia (2017)
   
Cytotoxic Drug Palbociclib (Ibrance)
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Restricted Drug Restricted
Red

Capsule

 
Link  NICE TA495 Palbociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer (2017)
   
Cytotoxic Drug Ponatinib (Iclusig)
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Restricted Drug Restricted
Red

Tablet

 
Link  NICE TA451 Ponatinib for treating chronic myeloid leukaemia and acute lymphoblastic leukaemia (2018)
   
Cytotoxic Drug Ribociclib (Kiskali)
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Restricted Drug Restricted
Red

Tablet

 
Link  NICE TA496 Ribociclib with an aromatase inhibitor for previously untreated, hormone receptor-positive, HER2-negative, locally advanced or metastatic breast cancer (2017)
   
Cytotoxic Drug Ruxolitinib (Jakavi®)
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Restricted Drug Restricted
Red

Tablets

 
   
Cytotoxic Drug Venetoclax (Venclyxto)
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Restricted Drug Restricted
Red

Tablet

 
Link  NICE TA487 Venetoclax for treating chronic lymphocytic leukaemia (2017)
   
08.01.05  Amsacrine
08.01.05  Arsenic trioxide to top
08.01.05  Bevacizumab
Bevacizumab (Avastin®)
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Formulary
Amber

Injection

 
Link  MHRA advice: Risk of osteonecrosis of the jaw ( 2011)
Link  NICE TA214: Breast Cancer with taxane
Link  NICE TA263: Breast cancer with capecitabine
   
08.01.05  Bexarotene
Bexarotene (Targretin®)
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Restricted Drug Restricted
Red

Capsule

 
   
08.01.05  Bortezomib
Bortezomib (Velcade®)
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Formulary
Red
Injection 
Link  NICE TA129: Multiple myeloma - bortezomib
Link  NICE TA228: Bortezomib and thalidomide for the first-line treatment of multiple myeloma
   
08.01.05  Brentuximab vedotin
08.01.05  Cetuximab to top
08.01.05  Crisantaspase
08.01.05  Dacarbazine and Temozolomide
Cytotoxic Drug Dacarbazine
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Formulary
Red
Injection 
   
08.01.05  Erlotinib
Cytotoxic Drug Erlotinib (Tarceva® )
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Formulary
Red

Tablets

 
Link  EMCN: Erlotinib regimen in lung cancer
   
08.01.05  Hydroxycarbamide
Cytotoxic Drug Hydroxycarbamide
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Formulary
Red
Capsules 
   
08.01.05  Imatinab to top
08.01.05  Ipilimumab
08.01.05  Mitotane
08.01.05  Panitumumab
08.01.05  Pentostatin
08.01.05  Platinum compounds to top
Cytotoxic Drug Carboplatin
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Formulary
Red
Injection 
   
Cytotoxic Drug Cisplatin
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Formulary
Red
Injection 
   
Cytotoxic Drug Oxaliplatin
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Formulary
Red
Injection 
   
08.01.05  Porfimer sodium and temoporfin
08.01.05  Procarbazine
Cytotoxic Drug Procarbazine
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Formulary
Red
 
   
08.01.05  Protein kinase inhibitors
Dasatinib (Sprycel®)
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Formulary
Red
Tablets 
   
Erlotinib (Tarceva®)
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Formulary
Red
Tablets 
   
Cytotoxic Drug Imatinib (Gilvec®)
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Formulary
Red
Tablets 
   
08.01.05  Taxanes
Cytotoxic Drug Docetaxel (Taxotere®)
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Formulary
Red
Concentrate for infusion 
   
Cytotoxic Drug Paclitaxel
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Formulary Concentrate for infusion 
   
08.01.05  Topoisomerase I inhibitors to top
08.01.05  Trabectedin
08.01.05  Trastuzumab
Cytotoxic Drug Trastuzumab (Herceptin®)
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Formulary
Red
Injection 
   
08.01.05  Tretinoin
Tretinoin (Vesanoid®)
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Formulary
Red
Capsules 
   
08.02  Drugs affecting the immune response
Brentuximab vedotin (Adcetris)
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Restricted Drug Restricted
Red

Injection

 
Link  NICE TA478 Brentuximab vedotin for treating relapsed or refractory systemic anaplastic large cell lymphoma (2017)
   
Cytotoxic Drug Nivolumab (Opdive)
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Restricted Drug Restricted
Red

Injection

 
Link  NICE TA462 Nivolumab for treating relapsed or refractory classical Hodgkin lymphoma (2017)
   
08.02  Immunosuppressant therapy to top
08.02.01  Antiproliferative immunosuppressants
Azathioprine
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Formulary Tablets 
Link  UKMI QA: Can mothers breast feed while taking azathioprine?
   
Mycophenolate Mofetil
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Formulary
Amber

Gastro-resistant tablets, tablets, capsules, oral suspension, injection.

 
   
08.02.02  Corticosteroids and other immunosuppressants
Tacrolimus (Advagraf®)
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Formulary Capsules m/r

Oral tacrolimus products - prescribe and dispense by brand name only 
   
Tacrolimus  (Modigraf®)
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Formulary Granules

Oral tacrolimus products - prescribe and dispense by brand name only 
   
Tacrolimus (Prograf®)
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Formulary Capsules

Oral tacrolimus products - prescribe and dispense by brand name only 
   
08.02.03  Anti-lymphocyte monoclonal antibodies
Alemtuzumab (MabCampath®)
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Formulary
Red
Injection 
   
Obinutuzumab (Gazyvaro)
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Restricted Drug Restricted
Red

Solution for infusion

 
Link  Obinutuzumab with bendamustine for treating follicular lymphoma refractory to rituximab
   
Cytotoxic Drug Rituximab (MabThera®)
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Formulary
Red
Injection

Pre-filled syringe (use restricted use)

 
   
08.02.04  Other immunomodulating drugs
Lenalidomide
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Formulary
Red
Tablets 
   
Cytotoxic Drug Pomalidomide (Innovid)
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Restricted Drug Restricted
Red
 
Link  NICE TA 427 Pomalidomide for multiple myeloma previously treated with lenalidomide and bortezomib (2017)
   
Thalidomide (Pharmion®)
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Formulary
Red
Capsules 
Link  Risk of thromboembolism - MHRA safety update
   
Dimethyl fumarate (Skilarence®)
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Restricted Drug Restricted
Red
 
   
08.02.04  Interferon Alfa to top
Peginterferon Alfa (Pegasys®)
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Formulary
Red
Prefilled syringe 
   
Peginterferon Alfa (ViraferonPeg®)
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Formulary
Red
Prefilled syringes 
   
08.02.04  Interferon beta
08.02.04  Aldesleukin
Bacillus Calmette-Guerin (OncoTICE®)
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Formulary
Red
Bladder instillation 
   
Bacillus Calmette-Guerin bladder instillation (ImmuCyst®)
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Formulary
Red
Bladder instillation 
   
08.02.04  Glatiramer acetate
08.02.04  Natalizumab
08.03  Sex hormones and hormone antagonists in malignant disease to top
08.03.01  Oestrogens
Diethylstilbestrol
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Formulary Tablets 
   
08.03.02  Progestogens
Medroxyprogesterone Acetate (Provera®)
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Formulary Tablets 
   
Megestrol Acetate (Megace®)
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Formulary Tablets 
   
Norethisterone
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Formulary Tablets 
   
08.03.03  Androgens
08.03.04  Hormone antagonists
08.03.04.01  Breast cancer to top
Anastrozole (Arimidex®)
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Formulary
Amber
Tablets 
   
Exemestane
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Formulary
Amber
Tablets 
   
Fulvestrant (Faslodex®)
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Formulary
Red
Injection 
Link  NICE TA239: Fulvestrant for the treatment of locally advanced or metastatic breast cancer
   
Letrozole
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Formulary Tablets 
   
Tamoxifen
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Formulary
Amber
Tablets 
   
08.03.04.02  Prostate cancer and gonadorelin analogues
08.03.04.02  Gonadorelin analogues
Degarelix (Firmagon®)
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Formulary Injection  
   
08.03.04.02  Anti-androgens
Bicalutamide (Casodex®)
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Formulary
Amber
Tablets 
   
Cyproterone Acetate (Cyprostat®)
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Formulary
Amber
Tablets 
   
Goserelin (Zoladex®)
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Formulary
Amber
Implant 3.6 mg 
   
Leuprorelin Acetate (Prostap® 3 )
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Formulary
Amber
Injection 3.5 mg 
   
Triptorelin (Decapeptyl® SR)
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Formulary Injection 3 mg 
   
08.03.04.03  Somatostatin analogues
Octreotide (Sandostatin®)
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Formulary Injection 
   
 ....
 Non Formulary Items
Anti-human thymocyte immunoglobulin (rabbit)  (Thymoglobuline®)

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Non Formulary
 
Ciclosporin

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Non Formulary
 
Crisantaspase  (Erwinase®)

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Non Formulary
 
Gefitinib  (Iressa®)

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Non Formulary
 
Goserelin-Zoladex®

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Non Formulary
 
Interferon Alfa

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Non Formulary
 
Interferon Alfa  (Roferon-A®)

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Non Formulary
 
Interferon Alfa  (Viraferon®)

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Non Formulary
 
Cytotoxic Drug  Irinotecan Hydrochloride  (Campto®)

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Non Formulary
 
Paclitaxel  (Abraxane®)

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Non Formulary
 
Paclitaxel  (Taxol®)

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Non Formulary
 
Peginterferon Alfa  (PegIntron®)

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Non Formulary
 
Prednisolone

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Non Formulary
 
Raltitrexed  (Tomudex®)

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Non Formulary
 
Sorafenib  (Nexavar®)

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Non Formulary
 
Sunitinib  (Sutent®)

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Non Formulary
 
Temoporfin  (Foscan®)

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Non Formulary
 
Thiotepa

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Non Formulary
 
Cytotoxic Drug  Tioguanine  (Lanvis®)

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Non Formulary
 
Cytotoxic Drug  Topotecan  (Hycamtin®)

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Non Formulary
Link  NICE TA91: Topotecan for ovarian cancer
 
  
Key
note Notes
Section Title Section Title (top level)
Section Title Section Title (sub level)
First Choice Item First Choice item
Non Formulary Item Non Formulary section
Restricted Drug
Restricted Drug
Unlicensed Drug
Unlicensed
Track Changes
Display tracking information
click to search medicines.org.uk
Link to adult BNF
click to search medicines.org.uk
Link to children's BNF
click to search medicines.org.uk
Link to SPCs
SMC
Scottish Medicines Consortium
Cytotoxic Drug
Cytotoxic Drug
CD
Controlled Drug
High Cost Medicine
High Cost Medicine
Cancer Drugs Fund
Cancer Drugs Fund
NHSE
NHS England
Homecare
Homecare
CCG
CCG

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